If you are using the official Stripe Payments extension from Stripe, you can experience some rendering and layout issues depending on your Magento configuration.

Symptoms: When Stripe Payments is enabled, the form for "I have a different billing address" does not render, and the Payment Methods is rendered in the wrong position.

Solution: Configure Magento to Display Billing Address On on Payment Page. See here for more details.

(Tested and verified with Magento 2.4.2, stripe/stripe-payments 2.5.7 and OneStepCheckout 1.2.046.)